Current Research
Our laboratory is currently focusing on two main directions:
1. Representational drift in the sensory cortex
2. Circuit-level alteration of sensory processing in autism sepctrum disorder (ASD) model mouse
Factors affecting representational drift in the primary sensory cortex
Representational drift is the ongoing changes in how neurons encode a particular stimulus or behaviorally relevant variable that occur without changes in behavior. We study the factors the will influence the speed and extent of changes in sensory representation of the primary sensory cortecis over time.
Cell-type specific stability of sensory tuning in L2/3PYR neurons
Examing which transcriptomic type of PYR neurons in L2/3 of primanry sensory cortex is prone to tuning changes over time.
Circuit-level changes in sensory coding of multiple ASD mouse models
Systemically investigate the response strength, tuning width, topography, and longterm sensory coding stability in primary cortical sensory neurons of multiple ASD mouse models including Shank3, Fmr1, Tsc2, Scn1a, etc.
The anatomic and developmental origin of sensory deficit in ASD mice
Using multi-site imaging and mouse genetics to dissect the origin of sensory coding alteration in ASD mice. Also examining the developmental spontaneous activity of ASD mice to investigate how early these sensory phenotypes emerge.
Claustral Regulation of Multi- sensory Processing and Cortical Network Dysfunction in ASD
Monicob project: characterizing the abnormalities in sensory processing (Wang lab), and correlating these findings with the anatomical and molecular changes (Chou lab) as well
as physiological changes (Chiu lab) in the clasutrum of two ASD mouse models: Fmr1 and Tsc2 mutants.